Ligand-Receptor Interactions and Drug Design

Ligand-receptor Interactions and Drug Design.

Biochemistry Insights aims to provide researchers working in this complex, quickly developing field with online, open access to highly relevant scholarly articles by leading international researchers. In a field where the literature is ever-expanding, researchers increasingly need access to up-to-date, high quality scholarly articles on areas of specific contemporary interest. This supplement a...

Ligand-receptor Interactions

The formation and dissociation of specific noncovalent interactions between a variety of macromolecules play a crucial role in the function of biological systems. During the last few years, three main lines of research led to a dramatic improvement of our understanding of these important phenomena. First, combination of genetic engineering and X ray cristallography made available a simultaneous...

Analysis of Receptor-Ligand Interactions.

Drug Receptor Interactions

The effects of a drug, the response you observe after administration, usually result from changes in physiological functions that lie well “downstream” from the primary site of drug action. In addition, the signaling pathways are making network in human body, so changing one system can affect the function of many other systems. Therefore the observed responses may represent both “direct” effect...

Drug Design: Structure- and Ligand-Based Approaches

Structure-based drug design (SBDD) and ligand-based drug design (LBDD) are active areas of research in both the academic and commercial realms. This book provides a current snapshot of the field of computer-aided drug design and associated experimental approaches. Topics covered include x-ray crystallography, nuclear magnetic resonance, fragment-based drug design, free-energy methods, docking a...